Nutritional Management in Severe Methylmalonic and Propionic Acidemias: How Much Medical Food Is Too Much?

J Inherit Metab Dis · 2026 · PMC12678014 · PMID 41344680

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a decreasing trendno p-value reported

Natural protein intake and total protein intake (expressed as a percentage of safe level WHO requirements) showed a decreasing trend over time, particularly in neonatal‐onset patients (Figure 3 ).

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did not reach statistical significanceno p-value reported

Total protein intake decreased with increasing clinical scores, although this change did not reach statistical significance in MMA patients (Figure 4B,E ).

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