SPP1/OPN Alleviates Post-Intracerebral Hemorrhage Depression and Cognitive Impairment via Nrf2/BDNF Signaling Activation in Mice.

Although the OPN intervention group demonstrated a non‐significant reduction in mortality compared to the control cohort, this difference did not reach statistical significance ( p > 0.05, Figure S1 ). 3.3 OPN Alleviates the Neurological Deficit Score Following Intracerebral Hemorrhage Following induction of intracerebral hemorrhage (ICH), both experimental groups exhibited a significant elevation in neurological deficit scores on postoperative day 1 (POD1), with subsequent progressive improvement over time (Figure 2A ).

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