Protective effects of treprostinil and ischemic preconditioning on hepatic ischemia-reperfusion injury and biomarkers in experimental studies in rats.

World J Gastrointest Surg · 2025 · PMC12679000 · PMID 41357620

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did not reach statistical significanceno p-value reported

According to our results, animals pretreated with IP presented greater myocardial damage after HIRI than after sham surgery, as evidenced by lower serum concentrations of troponin I ( P = 0.32) and CPK ( P = 0.10), but the difference did not reach statistical significance.

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a positive trendno p-value reported

The biphasic protection pattern of IP may explain the delayed cardioprotective effect observed, as neither the serum biomarkers nor the histopathological findings showed definitive significance, despite a positive trend.

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