Stratification of brain-derived extracellular vesicles of Alzheimer's disease patients indicates a unique proteomic content and a higher seeding capacity of small extracellular vesicles.

Transl Neurodegener · 2025 · PMC12679798 · PMID 41345709

Europe PMC DOI

hedged sentence

0.0630

closest p · 1.3× alpha

0.0630

boldest claim

The sentences

showed a trendP = 0.063so close (0.05 < p ≤ 0.1)

Notably, APOE—the most well-known AD GWAS-associated protein—was detected under all conditions and showed a trend toward increased levels in AD eLEVs compared to control eLEVs ( P = 0.063).

also in 53,322 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.