Androgen Receptors Promote Oxidative Phosphorylation and Resistance to Palmitate Lipotoxicity in ER-Mutant Breast Cancer.

We found that enzalutamide significantly inhibited, but did not completely suppress, proliferation of ER-mutant MCF7 Y537S and D538G cells and T47D D538G cells in media with standard (5.5mM) glucose availability, whereas T47D Y537S cells demonstrated a similar trend but did not reach statistical significance ( Fig. 1A and 1B ).

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