Barely Significant
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Impact of vaginal microbiota on the clinical efficacy and long-term recurrence of ketoconazole suppositories in treating severe vulvovaginal candidiasis: a secondary analysis of a multicentre randomised trial.

Front Cell Infect Microbiol · 2025 · PMC12682817 · PMID 41368434

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showed a trendno p-value reported
No significant inter-group differences were detected (P>0.05) in cure and recurrence rates, but the 36–49 y subset with abnormal flora showed a trend toward lower efficacy, which may be attributable to insufficient sample size.

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