In contrast, control mice receiving VPA showed a trend to increase astro- and microglial activation markers (no of activated cells and fluorescence intensity of GFAP and Iba1, respectively), accompanied by a significant increase of Etd + uptake in both astrocytes and microglia, indicating a potential proinflammatory effect of VPA.
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Boldo leaves reduce seizures, neuroinflammation, and hemichannel activity in a murine model of chronic epilepsy.
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