Moreover, the subset of open chromatin regions not detected as interacting with a gene promoter by Hi-C/PCC consistently exhibited the lowest level of heritability enrichment and generally failed to reach statistical significance compared to other biological constraints tested.
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3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility.
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The sentences
These traits exhibited highly significant enrichment, indicating that immune cell cREs captured a substantial fraction of heritability relative to their genomic span.