Clearing truncated tau protein restores neuronal function and prevents microglia activation in tauopathy mice.

Cell Rep · 2025 · PMC12684229 · PMID 40966081

Europe PMC DOI

hedged sentences

0.0001

closest p · 0.0× alpha

0.0690

boldest claim

The sentences

highly significantp < 0.0001actually significant

48 Analysis revealed a highly significant treatment and time effect and interaction between the two ( p < 0.0001 for all).

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a strong trendp = 0.069so close (0.05 < p ≤ 0.1)

A further western blot analysis clearly illustrated a reduction in 5G2 (60%, p < 0.0001) and a strong trend for reduction in 1G11 (32%, p = 0.069) cellular retention in the T21 KD cells in comparison to their respective naive cells (two-way ANOVA: treatment: p < 0.0001, T21 expression: p < 0.0001, and treatment × T21 interaction: p = 0.0004, Figures S3D – S3F ).

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