Ketone Catabolism Is Essential for Maintaining Normal Heart Function During Aging.

However, a 1.26‐fold increase in maximal respiratory capacity was observed with SCOT overexpression, showing a trend toward significance ( P =0.0634) (Figure 8B and 8C ), suggesting that upregulation of SCOT positively impacts mitochondrial function, promoting long‐term cellular survival and resistance to stress.

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Although SCOT cKO female mice exhibited not only systolic dysfunction but also cardiac remodeling, including a thinner ventricular wall, by 20 weeks of age (Figure 4 ), the ketogenic diet showed a trend toward attenuating the progression of contractile dysfunction and cardiac remodeling, mirroring the effects observed in male mice (Figure 7C and 7D ).

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