Nutrient supplementation mitigates retinal dysfunction in Acox1 knockout mice with impaired peroxisomal fatty acid oxidation.

J Adv Res · 2025 · PMC12684955 · PMID 40049514

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The combined diet significantly improved the rod signaling pathway between P30 and P60 (rod bipolar cell b- wave amplitude; P30, 353.9 ± 16.1 μV; P60, 400.8 ± 14.0 μV; p = 0.04; n = 13 eyes/group) and showed a trend towards an increase in the cone signaling pathway (cone bipolar cell b- wave amplitude; P30, 134.4 ± 11.1 μV; P60, 159.0 ± 11.8 μV; p = 0.14; n = 13 eyes/group) ( Fig. 4 G ).

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