Efficacy and Safety of Dexmedetomidine Nasal Spray as a Premedication in Patients Undergoing Fiberoptic Bronchoscopy Under Sedation: A Randomized Controlled Trial.

36 Although there was no significant difference in the dosage of fentanyl among the three groups, the dosage of fentanyl in Group D showed a decreasing trend, suggesting that dexmedetomidine may indirectly lower the risk of PONV by reducing opioid dosage, which requires further validation.

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Meanwhile, there were no significant differences between the three groups in terms of SpO 2 or the incidence of intraoperative respiratory depression, although Group D showed a trend toward a lower incidence of intraoperative respiratory depression.

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