Microneedle radiofrequency for skin rejuvenation: bridging image-derived metrics and photographic assessment.

Hydration interactions on the cheeks were nominally significant before multiplicity (right cheek β interaction = 3.58, p = 0.034, q = 0.103; left cheek β _interaction = 2.81, p = 0.017, q = 0.077) but did not meet the FDR threshold, which, given the modest sample and group imbalance (38 vs. 15), raises the possibility of both Type I (false positives) and Type II (false negatives).

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