Interestingly, the CDKN2A rs3731204 and BCL2 rs4940571 SNPs showed consistent directions of effect compared with the discovery phase and replicated with nominal significance (OR = 0.80, P = 8.72 × 10 −3 ; OR = 1.40, P = 8.66 × 10 −4 , respectively), whereas some SNPs such as BCL2 rs1026825 (OR = 1.06, P = .353) and BCL2 rs12457371 (OR = 0.92, P = .294) showed the same direction but did not reach statistical significance ( Table 1 ).
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Identification of 4 autophagy-related genetic variants as risk factors for chronic lymphocytic leukemia.
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