The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease by impairing microglial function.

Neuron · 2026 · PMC12687738 · PMID 41109213

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0.0551

closest p · 1.1× alpha

0.0551

boldest claim

The sentences

close-to-significantp = 0.0551so close (0.05 < p ≤ 0.1)

We found a modest and close-to-significant ( p = 0.0551) reduction in the percentage of cell surface Trem2 + cells in primary adult microglia of female 5xFAD;Trem2 T96K/T96K mice versus 5xFAD; Trem2 +/+ ( Figures S5C and S5D ).

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