a significant trendP=0.004
When the number of CVRFs was treated as a continuous variable, a significant trend of increased OS risk was observed in the chemotherapy subgroup (HR =1.32; 95% CI: 1.09–1.58; P=0.004), and a similar (though not statistically significant) trend was noted in the radiotherapy subgroup (HR =1.23; 95% CI: 0.98–1.53; P=0.08) ( Table 4 ).