Regenerative Therapy in Osteoarthritis Using Umbilical Cord-Origin Mesenchymal Stem Cells: A Critical Appraisal of Clinical Safety and Efficacy Through Systematic Review and Meta-Analysis.

Stem Cells Int · 2025 · PMC12688636 · PMID 41378180

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did not reach statistical significanceno p-value reported

Conclusion The present systematic review and meta-analysis provide evidence supporting the use of intra-articular UC-MSCs for improving function in knee osteoarthritis, with a trend toward pain reduction that did not reach statistical significance.

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