Cross-species validation of a 6-miRNA blood signature for Parkinson's disease: from MPTP mice to human PBMC and serum exosomes.

Front Neurol · 2025 · PMC12689404 · PMID 41383243

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

approached significancep = 0.060so close (0.05 < p ≤ 0.1)

Statistical significance was achieved in 2 of 3 cohorts using conservative permutation-based testing ( GSE269776 and GSE269775 , both p < 0.001), while GSE16658 approached significance ( p = 0.060).

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marginal significanceno p-value reported

Sample sizes in individual cohorts were modest, and the marginal significance in GSE16658 highlights the importance of larger validation studies ( 14 ).

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a trend toward significanceno p-value reported

The test statistic comparing time effects between MPTP and control groups yielded a one-sided p -value of 0.062 ( B = 5,000 permutations), showing a trend toward significance that suggests the observed pattern of miRNA changes in MPTP-treated animals may reflect genuine biological effects rather than random variation.

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