Personalized CRISPR knock-in cytokine gene therapy to remodel the tumor microenvironment and enhance CAR T cell therapy in solid tumors.

Nat Commun · 2025 · PMC12689812 · PMID 41366257

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a positive trendno p-value reported

did not reach statistical significanceno p-value reported

A positive trend in tumour-localized CAR T cell mass was observed for mice bearing cytokine-expressing tumours compared with those with unmodified tumours (+37% in SK-N-AS and +18% in SK-N-BE2c), although this did not reach statistical significance.

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