Transcriptomic analysis of <i>Streptococcus pneumoniae</i> serotype 1 reveals serotype-specific gene regulation.

Other genes which have been implicated in colonization, such as nagA , pavB and thiD , were turned on during the LEP (Table S2), although their expression did not reach statistical significance due to large variations. nagA has been associated with N -acetylglucosamine metabolism relevant for mucosal colonization [ 35 ], pavB encodes an adhesin known to mediate binding to host extracellular matrix proteins during colonization [ 58 ] and thiD has been linked to thiamine metabolism pathways that contribute to pneumococcal persistence in the host [ 59 ].

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