A decreasing trend in CD8/CD3 expression was noted as cancer progressed by tumor size, lymph node involvement, visceral pleural invasion, and clinical staging, although these differences were not statistically significant.
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Exploratory Immunohistochemical Profiling of FOXP3, PD-1 and CD32B in Resectable Lung Adenocarcinoma.
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Similarly, PD1 expression on T-cells, measured by the PD1/CD4 ratio, increased with cancer progression, but these differences also did not reach statistical significance.