IL-15 Complexes Combined with PD-1 Blockade Affect Immune Cell Distribution, Localization, and Immune Signatures in Regressing Versus Non-Regressing Metastatic Breast Tumors.

Although intratumoral treatment with IL-15 complexes did not induce significant upregulation in the cytokine and chemokine signaling pathway score, it did show an increasing trend in these treatment groups compared with groups treated with anti-PD-1 monotherapy and control (PBS/IgG isotype) ( Figure 4 E and Supplemental Figure S2B ).

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A similar trend was observe with IL-15 complex treatment alone compared with anti-PD-1 therapy and control (PBS/IgG isotype), but did not reach statistical significance.

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