Multiplex Immunofluorescence Assay with Opal Reagents for Identifying Mononuclear Cell Subsets in Kidney Allograft Rejection Types.

Int J Mol Sci · 2025 · PMC12692199 · PMID 41373718

Europe PMC DOI

hedged sentences

0.0900

closest p · 1.8× alpha

0.1060

boldest claim

The sentences

showed a trendp = 0.09so close (0.05 < p ≤ 0.1)

While Cox regression did not reveal statistically significant associations with graft survival, CD3 − PAX8 − CD16 + CD57 + cells showed a trend toward increased risk (HR = 2.73, p = 0.09).

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a trend towards significancep = 0.106not close (p > 0.1)

However, interstitial fibrosis and tubular atrophy (IFTA) showed a trend towards significance, with higher severity observed in ABMR cases ( p = 0.106).

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highly significantno p-value reported

Peritubular capillaritis (ptc) shows a highly significant difference among the three rejection types (NR, TCMR, and ABMR).

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