Proteomic Exploration of L1CAM<sup>+</sup>-Extracellular Vesicles from Plasma of Manifest and Prodromal Parkinson's Disease.

Moreover, among the 203 proteins that were nominally significant prior to multiple testing correction, 30 proteins exhibited a monotonic trend across disease progression, with 25 showing a stepwise increase and five showing a stepwise decrease in their mean abundance from HC → iRBD → PD ( Figure 2 B, Supplementary Tables S4 and S5 ).

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