Neuroprotective and Antioxidant Properties of Different Novel Steroid-Derived Nitrones and Oximes on Cerebral Ischemia In Vitro.

When comparing nitrone and oxime counterparts, nitrones from all three structural groups ( MC3 , MC5 and MC7 ) were consistently more potent and generally showed more efficacy than their corresponding oximes, although these differences did not reach statistical significance within group 3 ( MC6 and MC7 ), which overall exhibited the lowest EC 50 values ( Figure S1B,B ’, Supplementary Material ).

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