Barely Significant
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Parent-of-origin effects of phosphatidyl inositol-bisphosphate hydrolysis pathway genes on type 2 diabetes and the modification effect by obesity.

Front Endocrinol (Lausanne) · 2025 · PMC12695578 · PMID 41393296

Europe PMCDOI
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closest p · 1.0× alpha
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nominally significantP < 0.05actually significant
Results A total of 214 SNPs from the PIP2 hydrolysis pathway had nominally significant ( P < 0.05) POE on T2D, among which rs199684931 (RR m /RR p = 0.28, P interaction = 0.03), rs4750491 (RR m /RR p = 4.67, P interaction = 0.04), rs1090705 (RR m /RR p = 0.21, P interaction = 0.04), rs9663645 (RR m /RR p = 4.75, P interaction = 0.04), and rs200488869 (RR m /RR p = 4.75, P interaction = 0.04) from PRKCQ exhibited POE–BMI interactions.

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