A genome-wide association study of mass spectrometry proteomics using a nanoparticle enrichment platform.

An association reported by deCODE and Olink was considered as significant at levels of P < 5 × 10 −8 and as marginally significant P < 0.05 and P > 5 × 10 −8 .

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The primary reason for the nonreplicated pQTLs is the limited size of the replication cohort: of 70 pQTLs that had 80% replication power, 58 (82.9%) replicated and most (36 out of 38) of the nominally significant ( P < 0.05) pQTLs had concordant directionality, suggesting that most of the unreplicated pQTLs should be replicable in future larger-scale studies.

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