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Shaoyao gancao decoction induces autophagy by modulating miR-21 and inhibiting the AKT/mTOR signaling pathway in adenomyosis-derived ectopic endometrial stromal cells.

Front Pharmacol · 2025 · PMC12695794 · PMID 41394131

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When comparing AM eutopic endometrium to normal endometrium, there was a marked decrease in the expression of p-UKL1, LC3B, and Beclin 1 protein (Beclin-1) ( P < 0.05, P < 0.01); however, the increase observed in Bcl-2 expression did not reach statistical significance.

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