Single-cell transcriptomic analysis reveals a systemic immune dysregulation in intravenous immunoglobulin non-responsive Kawasaki disease.

Among T and NK cells, naive or proliferative cells (CD8_Naive and NK_Pro) were enriched, while effector T-cell subsets (CD4_Tfh, CD4_Treg and CD8_Effector) showed a decreasing trend ( Figure 1D ; Supplementary Figure 4 ).

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Consistent with our scRNA-seq data, we found that plasma IFN-α levels showed an elevated trend in IVIG non-responders ( Supplementary Figure 10E ).

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Among these, IFITM1 , IFITM3 , IRF1 , and IFNGR2 exhibited an increasing trend ( Supplementary Figure 10G ).

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Although likely influenced by the limited sample size, the ELISA results did not reach statistical significance.

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