CAR T-cell therapy for neurological disorders: scientific rationale and mechanistic insights.

Even though there is growing evidence that clonal hematopoiesis of indeterminate significance may indeed be more prevalent in AID-patients compared to the general population, this need not necessarily be true compared to cancer patients. 125 , 126 The increased preexisting genomic hits and germline mutations in this patient group may further confound the extrapolation. 127 Conversely, the integration of genetic sequences into the host genome—even when restricted to T cells and despite advances in vector safety—carries the potential risk of insertional mutagenesis, which may drive malignant transformation.

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