Combining evidence from human genetic and functional screens to identify pathways altering obesity and fat distribution.

While the 19 exome-wide significant genes were not significantly associated (all p > 4.38 × 10 −4 , Bonferroni adjustment for 19 unique genes × 6 phenotypes) with any other tissue-specific fat components, we observed that nominally significant associations ( p < 0.05) generally shared the expected direction of effect on the primary and supplemental phenotypes ( Figures 2 and S3 ).

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