Thrombocytopenia in murine schistosomiasis is associated with platelet uptake by liver macrophages that have a distinct activation phenotype.

Whilst there was no significant difference in the proportion of RELMα + macrophages, there was an increasing trend (p = 0.07) in Mpl -/- eosinophils following infection ( S7L Fig ).

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Platelets have been shown to aid immune cell recruitment to inflammatory sites [ 11 , 14 , 54 – 56 ] and here we show romiplostim significantly increased liver monocyte and neutrophil PLA, with a strong trend to increase also seen for macrophages ( Fig 6D ).

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