Thymoquinone Inhibits Proliferation and Induces Apoptosis in Immortalized Keratinocytes via Upregulation of p53 Expression.

For BCL-xl ( Figure 3(b) ), a reduction in expression was observed in the treated group (0.6918 ± 0.8602) compared to the control (1.000 ± 0.000), although this difference did not reach statistical significance ( p > 0.05).

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Collectively, these findings suggest that the treatment markedly induces p53 expression, while exhibiting a nonsignificant trend toward downregulation of BCL-xl and upregulation of Bax, potentially indicating a shift in the apoptotic balance. 4.

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