Co-expression-wide association studies link genetically regulated interactions with complex traits.

Nat Commun · 2025 · PMC12698763 · PMID 41381446

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hedged sentences

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closest p · 0.0× alpha

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boldest claim

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highly significantP < 1e−50actually significant

Furthermore, COWAS discovered a highly significant effect of the interaction between APOE and LDLR on AD risk ( P < 1e−50).

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nominally significantP < 0.05actually significant

Depending on the model type selected, between 8% and 19% of protein pairs exhibited a nominally significant correlation ( P < 0.05) between predicted and observed expression/co-expression in all three models, but this percentage rose to over 99% in well-imputed pairs.

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