Macrophage Subtypes Distinctly Impact Intervertebral Disc Inflammation and Extracellular Matrix Composition.

JOR Spine · 2025 · PMC12700309 · PMID 41394791

Europe PMC DOI

hedged sentences

0.0590

closest p · 1.2× alpha

0.0960

boldest claim

The sentences

a decreasing trendp = 0.059so close (0.05 < p ≤ 0.1)

In the IVD + TNFα group, NO release decreased from Day 4 to Day 14 ( p < 0.01) with a decreasing trend from Day 11 to Day 14 ( p = 0.059; Figure 6A ).

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showed a trendp = 0.068so close (0.05 < p ≤ 0.1)

Without TNFα stimulation, M1 macrophages in co‐culture with IVD explants showed a trend towards decreased expression of Arg1 ( p = 0.068) and a significant decrease in expression of Spint1 ( p < 0.05) compared to M1 macrophages alone, while M2 co‐cultured macrophages had a trending decrease in Arg1 ( p = 0.085) and a significant decrease in Maob compared to M2 macrophages alone ( p < 0.01; Figure S5A ).

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an increasing trendp = 0.096so close (0.05 < p ≤ 0.1)

An increasing trend was seen in TNFα + M2 compared to IVD + TNFα + M2 at Day 7 ( p = 0.096) and 14 ( p = 0.060; Figure 8I ).

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