Preclinical safety and burn wound healing activity of "Novostron", a novel topical iodine-based therapeutic.

Statistical analysis supported these findings: two-way repeated-measures ANOVA showed a highly significant treatment effect (p < 0.0001), with Dunnett’s post hoc tests revealing intense erythema and edema responses only in the positive control (MD 1.48–3.83, p < 0.0001), while Novostron did not differ from the negative control at any observation point.

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Although dexamethasone showed a decreasing tendency toward (MD = −166.0, 95% CI: –371.4 to 39.29) and Novostron showed a slight increase compared with the 0.9% NaCl group (MD = 36.4, 95% CI: −168.9 to 241.7), these changes did not reach statistical significance ( Fig 9H ).

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