The cell-type-specific genetic architecture of chronic pain in brain and dorsal root ganglia.

In the hDRG, hPEP.PIEZOh, hNP1, and hTRPM8 were nominally significant ( P < 0.05) cell types among females, and hPEP.TRPV1/A1.2, hAδ.LTMR, and hTRPM8 were nominally significant among males, though none of these cell types was significantly enriched after correction for multiple testing ( Supplemental Figure 1B and Supplemental Table 12 ).

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First, although the genetic correlations among pain phenotypes in the meta-analysis were highly significant and positive, they were far from unity (MVP vs.

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