Developmental modulation of schizophrenia risk gene methylation in offspring exhibiting cognitive deficits following maternal immune activation.

Between-group analysis of molecular outputs used a general linear mixed model (GLMM), including dam as a random factor and the following predictors: fixed factors (sex, group) and co-variates (maternal IL-6 and TNFα), with p-values ≤ 0.05 considered statistically significant and 0.05 < p ≤ 0.075 highlighted as approaching significance.

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The RRBS gene list was also compared to differentially methylated genes identified from a MIA mouse model [ 62 ], which showed a highly significant (>50%) overlap with 2331 genes differentially methylated in both studies (Fig. 6 ).

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