Blood steroid hormone profile and clinical outcomes following switching from metyrapone to osilodrostat in patients with Cushing disease.

Endocr J · 2025 · PMC12702669 · PMID 40887254

Europe PMC DOI

hedged sentences

0.0780

closest p · 1.6× alpha

0.0780

boldest claim

The sentences

a decreasing trendp = 0.078so close (0.05 < p ≤ 0.1)

Furthermore, 11-DOF also showed a decreasing trend ( p = 0.078), with improvements in clinical symptoms including masculinization signs and hypertension.

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showed a trendno p-value reported

ACTH was significantly increased after the switch to osilodrostat, and previous reports showed a trend of increased ACTH with osilodrostat, although the difference was not significant [ 6 , 10 ].

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