Circulating cell adhesion molecules as biomarkers in inflammatory bowel disease: a systematic review and meta-analysis.

This finding was consistent in sensitivity analysis (SMD ranged from 0.09 to 0.29), although exclusion of the UC subgroup from the Patel study ( 42 ) resulted in a borderline significant difference favoring higher sVCAM-1 levels in the active disease group (SMD 0.29, 95% CI –0.001 to 0.58, p=0.050).

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Among the biomarkers analyzed, all showed a trend toward higher concentrations in IBD patients; however, only sICAM-1 and sE-selectin reached statistical significance.

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