Extracellular Matrix-MYCAF Signatures Correlate with Resistance to Neoadjuvant aPD-L1 Immune Checkpoint Inhibition with Durvalumab + Metformin in HPV+ HNSCC.

Clin Cancer Res · 2025 · PMC12703361 · PMID 40932382

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showed a trendno p-value reported

Consistent with the IFNγ signature enrichment in responders, baseline responders showed a trend toward differential enrichment of several favorable lymphoid populations in the PanCKe segment; notably, the CD163e segment showed enrichment in B cells in responders (Supplementary Fig.

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