Macrovascular tumor infiltration and circulating tumor cell cluster dynamics in patients with cancer approaching the end of life.

Interestingly, the acceleration in CTC counts observed in patients nearing death emerged from an underlying upward trajectory, although this trend did not reach statistical significance (Supplementary Figs. 9 and 10 ).

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Notably, these associations remained highly significant even after adjusting for age, sex, presence (and timing) of distant metastasis and resection status (Fig. 3c (right) and Supplementary Fig. 32 ).

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