CSF and plasma levels of AMD and CSF levels of cystatin M showed nominally significant associations ( P < 0.05) with microbleeds in plasma ( Supplementary Table 6 ), in the same direction as significant associations with WMHs and WM-PVSs, respectively.
Genes encoding cSVD-associated proteins showed a nonsignificant trend toward enrichment in pericytes and significant enrichment in a microglial state type overrepresented in processes such as ribosome biogenesis, amyloid fibril formation and regulation of T cell-mediated immunity ( Extended Data Fig. 9 ) 35 .
PRSS8, associated with WMH, also shows a highly significant association with risk of incident stroke and dementia in observational analyses.