Barely Significant
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Direct interaction between TDP-43 and Tau promotes their co-condensation, while suppressing Tau fibril formation and seeding.

EMBO J · 2025 · PMC12706024 · PMID 41107545

Europe PMCDOI
1
hedged sentence
0.0568
closest p · 1.1× alpha
0.0568
boldest claim

The sentences

did not reach statistical significanceP = 0.0568so close (0.05 < p ≤ 0.1)
Although the difference between the aggregate area in AD+ and FTLD-TDP samples did not reach statistical significance ( P = 0.0568), these data suggest that AD+ brains harbor highly TDP-43 seeding-competent species.

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