Circulating monocytes from systemic sclerosis patients with progressive interstitial lung disease preferentially express M2 phenotype markers: in vitro and ex vivo study.

Moreover, the protein synthesis of CD206 and MerTK was significantly higher in cultured MDMs obtained from SSc patients with progressive ILD compared with non-progressive ILD SSc patients (p<0.05 for both), whereas CD163 protein synthesis showed a trend to higher value that was non-statistically significant (mean±SD protein synthesis CD163: 7.79±6.8 vs 3,23±1.8) ( figure 3A–D ).

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