Preserved cognitive-functional phenotype in centenarians and its association with modifiable risk factors for dementia: Results from the Colombian centenarians project.

55 Yet, its borderline significance suggests bidirectionality, depression may act both as a risk factor and as an early manifestation of neurodegeneration, complicating causal interpretation. 55 Physical activity frequency was not significantly related to PCFP, but objectively measured performance (SPPB) showed a strong associa

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9 Depression showed a trend toward a negative association with cognitive status, highlighting the role of emotional well‐being in sustaining cognitive vitality. 55 Yet, its borderline significance suggests bidirectionality, depression may act both as a risk factor and as an early manifestation of neurodegeneration, compli

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