Exercise-responsive circTSN as a potential systemic biomarker during COPD rehabilitation.

Although these changes did not reach statistical significance, the directionality of expression was consistent with that observed in patient samples, suggesting a similar molecular response to pulmonary rehabilitation in mice.

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In line with the human findings, circTSN expression in lung tissues showed a decreasing trend in COPD mice and a partial restoration following treadmill exercise, whereas miR-144-3p exhibited the opposite pattern ( Figures 2E , F ).

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