a positive trendp = 0.102
A tendency toward a positive trend in adherence rates was identified in the period 2019–2021 among subjects with humerus or wrist (Supplementary Fig. 3 , panel b, test for trend p = 0.102) and vertebra (panel c, test for trend p = 0.602) index FFs, while the trend remained even more blunted among subjects with hip index FFs (panel d, test for trend p = 0.107).