Blood-based protein biomarkers of sickle cell disease pain: a systematic review and meta-analysis.

Pain · 2026 · PMC12709642 · PMID 40981515

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trending towards significanceno p-value reported

150 This meta-analysis showed sE-selectin and soluble vascular cell adhesion molecule-1 (sVCAM-1) levels were significantly higher during VOE compared with steady state, with soluble P-selectin and intracellular adhesion molecule-1 (ICAM-1) levels during VOE trending towards significance.

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