Plasma Protein Profile Associated With a Family History of Early-Onset Coronary Heart Disease.

In MR, LPL showed a trend towards an inverse causal relationship with CHD, in line with previous studies indicating a higher risk of CHD in subjects with loss-of-function variants of LPL, as well as a protective relationship between triglyceride-lowering LPL variants and CHD in MR analyses. 23 PON3 inhibits LDL-oxidation and has been shown to slow atherosclerosis progression. 24 In this study, PON3 was strongly negatively associated with both family history of CHD and SIS; however, it did not meet the corrected significance level in our MR analysis.

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We also noted a trend towards significance for additional proteins, such as LPL and MMP-12, both with negative directions of effect in relation to myocardial infarction.

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